You have found the Cook Group home page in the Department of Chemistry and Biochemistry at North Dakota State University.
The Cook Research Group has three main areas of focus:
1) the development of environmentally friendly synthetic methodology to enable asymmetric synthesis;
2) the total synthesis of molecules with potential benefits to the human race as new materials and/or have important biological function;
3) the discovery of new small molecules that impact human medicine.
In our efforts toward those major goals we have developed new asymmetric allylation methods for the selective generation of chiral amines utilizing environmentally benign indium and bismuth catalysts. We are showcasing our new methods by carrying out the total synthesis of structurally interesting natural products. And we are targeting cancer, heart disease and other autoimmune diseases through the development of novel inhibitors and activators for histone deacetylases. These enzymes are responsible for epigenetic regulation of tumor suppressors and other genes.
Latest Paper from the Cook Group
Binding Thermodynamics of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in Rational Design of Potent and Isozyme-selective Inhibitors of the Enzyme
Of different histone deacetylase (HDAC) isozymes, HDAC8 is a highly malleable enzyme, and it exhibits the potential to accommodate structurally diverse ligands (albeit with moderate binding affinities) in its active site pocket. To probe the molecular basis of this feature, we performed the detailed thermodynamic studies for the binding of structurally similar ligands, which differed… Read More