A new route for the synthesis of 2-aminopyridines has been developed that merges C–H functionalization with amide alcoholysis. The key component of this method is the ability of a quinazolinone to template the chemo- and regioselective construction of a latent pyridine ring via site-selective olefinic C–H bond functionalization under Ru(II) catalysis. Thus, highly substituted 2-aminopyridines […]
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Welcome To our PICNICS student this summer. Atiya Khan joins us from Davies High School.
Cook Group News
- Merging C–H Bond Functionalization with Amide Alcoholysis: En Route to 2-Aminopyridines
- Highly chemo- and regioselective allylic substitution with tautomerizable heteroarenes
- N-Boc-glycine-assisted indium-mediated allylation reaction: A sustainable approach
- Highly Diastereoselective Palladium-Catalyzed Indium-Mediated Allylation of Chiral Hydrazones
- Binding Thermodynamics of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in Rational Design of Potent and Isozyme-selective Inhibitors of the Enzyme